|Description:||Rabbit polyclonal antibody to Fibrillarin.|
|Dilutions:||WB 1:500 - 1:1000|
|Immunogen:||A synthetic peptide of human FBL|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at 4℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).|
|Sequence Similarities:||Belongs to the methyltransferase superfamily. Fibrillarin family.|
|Post-Translational Modification:||By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).|
|Cellular Location:||Nucleus > Nucleolus.
Fibrillar region of the nucleolus.
|Synonyms:||34 kD nucleolar scleroderma antigen Antibody
34 kDa nucleolar scleroderma antigen Antibody
Histone-glutamine methyltransferase Antibody
RNA U3 small nucleolar interacting protein 1 Antibody
rRNA 2' O methyltransferase fibrillarin Antibody
rRNA 2'-O-methyltransferase fibrillarin Antibody
Western blot analysis of extracts of K562 cells, using FBL antibody.