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Anti-Fibrillarin Antibody

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Name: Anti-Fibrillarin Antibody
Description: Rabbit polyclonal antibody to Fibrillarin.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human FBL
Protein Length: 321
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239).
Sequence Similarities: Belongs to the methyltransferase superfamily. Fibrillarin family.
Post-Translational Modification: By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
Cellular Location: Nucleus > Nucleolus.

Fibrillar region of the nucleolus.
UniProt: P22087
Gene ID: 2091
Synonyms: 34 kD nucleolar scleroderma antigen Antibody
34 kDa nucleolar scleroderma antigen Antibody
Fbl Antibody
FIB Antibody
FIB1 Antibody
FLRN Antibody
Histone-glutamine methyltransferase Antibody
Nop1p Antibody
RNA U3 small nucleolar interacting protein 1 Antibody
RNU3IP1 Antibody
rRNA 2' O methyltransferase fibrillarin Antibody
rRNA 2'-O-methyltransferase fibrillarin Antibody

Western Blot - Anti-Fibrillarin Antibody from ABclonal (A0158) - Antibody Supply Service
Western blot analysis of extracts of K562 cells, using FBL antibody.

Product Code - A0158
Size Price Quantity
100µl £243
200µl £372

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