|Description:||Rabbit polyclonal antibody to NRAS.|
|Applications:||WB, IHC, FC|
|Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:100, FC 1:20 - 1:50|
|Immunogen:||A synthetic peptide of human NRAS|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at 4℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.|
|Involvement in Disease:||Leukemia, juvenile myelomonocytic: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages.
Noonan syndrome 6: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
RAS-associated autoimmune leukoproliferative disorder: A disorder of apoptosis, characterized by chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, and an increased risk for the development of hematologic malignancies.
Melanocytic nevus syndrome, congenital: A syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip.
Melanosis, neurocutaneous: A rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma.
Keratinocytic non-epidermolytic nevus: Epidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood.
Thyroid cancer, non-medullary, 2: A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
|Sequence Similarities:||Belongs to the small GTPase superfamily. Ras family.|
|Post-Translational Modification:||Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.|
|Cellular Location:||Cell membrane. Golgi apparatus membrane.
Shuttles between the plasma membrane and the Golgi apparatus.
C K RAS Antibody
c K ras protein Antibody
c K ras2 protein Antibody
c Ki ras Antibody
C Kirsten ras protein Antibody
Cellular c Ki ras2 proto oncogene Antibody
GTPase HRas Antibody
GTPase KRas Antibody
GTPase NRas Antibody
K Ras 2 Antibody
K ras p21 protein Antibody
K RAS2A Antibody
K RAS2B Antibody
K RAS4A Antibody
K RAS4B Antibody
K-Ras 2 Antibody
KI RAS Antibody
Kirsten rat sarcoma 2 viral (v Ki ras2) oncogene homolog Antibody
N ras Antibody
N ras + c Ha ras Antibody
N ras protein part 4 Antibody
N-terminally processed Antibody
Neuroblastoma RAS viral (v ras) oncogene homolog Antibody
Neuroblastoma RAS viral (v-ras) oncogene homolog Antibody
oncogene KRAS2 Antibody
p21 Ras Antibody
PR310 c K ras oncogene Antibody
Ras family small GTP binding protein H Ras Antibody
Transforming protein N Ras Antibody
Transforming protein N-Ras Antibody
Transforming protein p21 Antibody
v Ha ras Harvey rat sarcoma viral oncogene homolog Antibody
v Ki ras2 Kirsten rat sarcoma viral oncogene homolog Antibody
v ras neuroblastoma RAS viral oncogene homolog Antibody
Western blot analysis of extracts of C6 cell line, using NRAS antibody.