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Anti-HP1α Antibody

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ABclonal
A0132
Overview
Name: Anti-HP1α Antibody
Description: Rabbit polyclonal antibody to HP1α.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human CBX5
Protein Length: 191
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Post-Translational Modification: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
Cellular Location: Nucleus. Chromosome. Chromosome > Centromere.

Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
UniProt: P45973
Gene ID: 23468

Images
Western Blot - Anti-HP1α Antibody from ABclonal (A0132) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using CBX5 antibody.

Product Code - A0132
Size Price Quantity
100µl £243
200µl £372

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