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Anti-p63 Antibody

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ABclonal
A0089
Overview
Name: Anti-p63 Antibody
Description: Mouse monoclonal antibody to p63.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human TP63
Protein Length: 680
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Tissue Specificity: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Involvement in Disease: Acro-dermato-ungual-lacrimal-tooth syndrome: A form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting.

Ankyloblepharon-ectodermal defects-cleft lip/palate: An autosomal dominant condition characterized by congenital ectodermal dysplasia with coarse, wiry, sparse hair, dystrophic nails, slight hypohidrosis, scalp infections, ankyloblepharon filiform adnatum, maxillary hypoplasia, hypodontia and cleft lip/palate.

Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant syndrome characterized by ectrodactyly of hands and feet, ectodermal dysplasia and facial clefting.

Split-hand/foot malformation 4: A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.

Limb-mammary syndrome: Characterized by ectrodactyly, cleft palate and mammary-gland abnormalities.

Ectodermal dysplasia, Rapp-Hodgkin type: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Characterized by the combination of anhidrotic ectodermal dysplasia, cleft lip, and cleft palate. The clinical syndrome is comprised of a characteristic facies (narrow nose and small mouth), wiry, slow-growing, and uncombable hair, sparse eyelashes and eyebrows, obstructed lacrimal puncta/epiphora, bilateral stenosis of external auditory canals, microsomia, hypodontia, cone-shaped incisors, enamel hypoplasia, dystrophic nails, and cleft lip/cleft palate.

Non-syndromic orofacial cleft 8: A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum.
Sequence Similarities: Belongs to the p53 family.
Post-Translational Modification: May be sumoylated.
Cellular Location: Nucleus.
UniProt: Q9H3D4
Gene ID: 8626
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CCT alpha Antibody
CCT-alpha Antibody
CCT1 Antibody
Ccta Antibody
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Chronic ulcerative stomatitis protein Antibody
CK13 Antibody
CK14 Antibody
CK15 Antibody
CK16 Antibody
CKAP 4 Antibody
CKAP4 Antibody
CKAP4_HUMAN Antibody
CUSP Antibody
Cytokeratin 13 Antibody
Cytokeratin 14 Antibody
Cytokeratin 15 Antibody
Cytokeratin 16 Antibody
Cytoskeleton associated protein 4 Antibody
Cytoskeleton-associated protein 4 Antibody
D6S230E Antibody
DHTX Antibody
Disrupted in heterotaxy Antibody
DN p63 alpha 1 Antibody
DNp63 Antibody
EEC3 Antibody
ERGIC 63 Antibody
ERGIC63 Antibody
id:ibd3516 Antibody
K13 Antibody
K14 Antibody
K15 Antibody
K16 Antibody
Keratin 13 Antibody
Keratin 14 Antibody
Keratin 15 Antibody
Keratin 16 Antibody
Keratinocyte transcription factor Antibody
Keratinocyte transcription factor KET Antibody
KET Antibody
KRT13 Antibody
KRT14 Antibody
KRT15 Antibody
KRT16 Antibody
LCA 2 Antibody
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Leber congenital amaurosis Antibody
LMS Antibody
MGC115972 Antibody
MGC133746 Antibody
MGC192897 Antibody
MGC99554 Antibody
mRPE 65 Antibody
mRPE65 Antibody
NBP Antibody
OFC8 Antibody
OTTHUMP00000209732 Antibody
OTTHUMP00000209733 Antibody
OTTHUMP00000209734 Antibody
OTTHUMP00000209735 Antibody
OTTHUMP00000209737 Antibody
OTTHUMP00000209738 Antibody
OTTHUMP00000209739 Antibody
OTTHUMP00000209740 Antibody
OTTHUMP00000209741 Antibody
OTTHUMP00000209742 Antibody
OTTHUMP00000209743 Antibody
OTTHUMP00000209744 Antibody
p40 Antibody
p51 Antibody
P51/P63 Antibody
p51A Antibody
p51B Antibody
p53-related protein p63 Antibody
p53CP Antibody
p63 (phospho S395) Antibody
p63 (phospho S455) Antibody
p63 Protein + HMW Cytokeratin Antibody
P63_HUMAN Antibody
p73H Antibody
p73L Antibody
rd 12 Antibody
rd12 Antibody
Retinal pigment epithelium specific 61 kDa protein Antibody
Retinal pigment epithelium specific 65 kDa protein Antibody
Retinal pigment epithelium specific protein Antibody
Retinal pigment epithelium specific protein 65kDa Antibody
Retinal pigment epithelium-specific 65 kDa protein Antibody
Retinitis pigmentosa 20 Antibody
Retinoid isomerohydrolase Antibody
Retinol isomerase Antibody
RHS Antibody
RP 20 Antibody
RP20 Antibody
RPE 65 Antibody
RPE65 Antibody
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SHFM4 Antibody
sRPE 65 Antibody
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T complex 1 Antibody
T complex protein 1 Antibody
T complex protein 1 alpha subunit Antibody
T-complex homolog TCP1 Antibody
T-complex protein 1 subunit alpha Antibody
T-complex protein 1 subunit alpha B Antibody
Tailless complex polypeptide 1 Antibody
Tailless complex polypeptide 1A Antibody
Tailless complex polypeptide 1B Antibody
TAp63alpha Antibody
TCP 1 alpha Antibody
Tcp-1 Antibody
TCP-1-alpha Antibody
TCP1 Antibody
TCP1 alpha Antibody
TCPA_HUMAN Antibody
TP53CP Antibody
TP53L Antibody
TP63 Antibody
TP73L Antibody
Transformation related protein 63 Antibody
Transformation-related protein 63 Antibody
Transmembrane protein 63kD endoplasmic reticulum Golgi intermediate compartment Antibody
TRic Antibody
Trp53rp1 Antibody
Trp63 Antibody
Tumor protein 63 Antibody
Tumor protein p53 like Antibody
Tumor protein p53-competing protein Antibody
Tumor protein p53-like Antibody
Tumor protein p63 Antibody
Tumor protein p63 deltaN isoform delta Antibody
Tumor protein p73 Antibody
Tumor protein p73 like Antibody
Tumor protein p73-like Antibody
Type II transmembrane protein p63 Antibody
UV radiation resistance associated Antibody
UV radiation resistance associated gene Antibody
UV radiation resistance associated gene protein Antibody
UV radiation resistance-associated gene protein Antibody
UVRAG Antibody
UVRAG_HUMAN Antibody

Images
Western Blot - Anti-p63 Antibody from ABclonal (A0089) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using TP63 antibody.

Product Code - A0089
Size Price Quantity
100µl £243
200µl £372

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