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Anti-E2F-1 Antibody

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ABclonal
A0051
Overview
Name: Anti-E2F-1 Antibody
Description: Rabbit polyclonal antibody to E2F-1.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic peptide of human E2F1
Protein Length: 437
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
Sequence Similarities: Belongs to the E2F/DP family.
Post-Translational Modification: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.
Cellular Location: Nucleus.
UniProt: Q01094
Gene ID: 1869
Synonyms: DmelCG6376 Antibody
Dmel_CG6376 Antibody
drosE2F1 Antibody
E(Sev-CycE)3A Antibody
E(var)3-93E Antibody
E2-promoter binding facto Antibody
E2F 1 Antibody
E2F transcription factor 1 Antibody
E2f-PA Antibody
E2f-PB Antibody
E2f-PC Antibody
E2F1 Antibody
E2F1 (phospho S337) Antibody
E2F1 (phospho S364) Antibody
E2F1 (phospho T433) Antibody
E2f1 E2F transcription factor 1 Antibody
E2F1_HUMAN Antibody
Evar(3)164 Antibody
KIAA4009 Antibody
l(3)07172 Antibody
l(3)j3B1 Antibody
l(3)j3C2 Antibody
l(3)rM729 Antibody
mKIAA4009 Antibody
OTTHUMP00000030661 Antibody
PBR3 Antibody
PRB binding protein E2F 1 Antibody
PRB-binding protein E2F-1 Antibody
RBAP 1 Antibody
RBAP-1 Antibody
RBAP1 Antibody
RBBP-3 Antibody
RBBP3 Antibody
RBP 3 Antibody
RBP3 Antibody
Retinoblastoma-associated protein 1 Antibody
Retinoblastoma-binding protein 3 Antibody
Transcription factor E2F1 Antibody

Images
Western Blot - Anti-E2F-1 Antibody from ABclonal (A0051) - Antibody Supply Service
Western blot analysis of extracts of HeLa cell line, using E2F1 antibody.

Product Code - A0051
Size Price Quantity
100µl £243
200µl £372

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