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Anti-Cathepsin D Antibody

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ABclonal
A0041
Overview
Name: Anti-Cathepsin D Antibody
Description: Rabbit polyclonal antibody to Cathepsin D.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human CTSD
Protein Length: 412
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation (PubMed:27333034). Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.
Tissue Specificity: Expressed in the aorta extrcellular space (at protein level) (PubMed:20551380). Expressed in liver (at protein level) (PubMed:1426530).
Involvement in Disease: Ceroid lipofuscinosis, neuronal, 10: A form of neuronal ceroid lipofuscinosis with onset at birth or early childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
Sequence Similarities: Belongs to the peptidase A1 family.
Post-Translational Modification: N- and O-glycosylated.
Cellular Location: Lysosome. Melanosome. Secreted > Extracellular space.

Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380).
UniProt: P07339
Gene ID: 1509
Synonyms: CatD Antibody
CATD_HUMAN Antibody
cathepsin D (lysosomal aspartyl protease) Antibody
Cathepsin D heavy chain Antibody
CD Antibody
Ceroid lipofuscinosis neuronal 10 Antibody
Ceroid-lipofuscinosis, neuronal 10 Antibody
CLN10 Antibody
CPSD Antibody
ctsd Antibody
EC 3.4.23 Antibody
EC 3.4.23.5 Antibody
Epididymis secretory sperm binding protein Li 130P Antibody
HEL S 130P Antibody
Lysosomal aspartyl peptidase Antibody
Lysosomal aspartyl protease Antibody
MGC2311 Antibody
OTTHUMP00000042282 Antibody
OTTHUMP00000196039 Antibody
OTTHUMP00000198692 Antibody
proCathepsin D Antibody

Images
Western Blot - Anti-Cathepsin D Antibody from ABclonal (A0041) - Antibody Supply Service
Western blot analysis of extracts of HepG2 cell line, using CTSD antibody.

Product Code - A0041
Size Price Quantity
100µl £243
200µl £372

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