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Anti-MET Antibody

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ABclonal
A0040
Overview
Name: Anti-MET Antibody
Description: Rabbit polyclonal antibody to MET.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: Recombinant protein of human MET
Protein Length: 1390 (1408)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
Tissue Specificity: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain. Expressed in metaphyseal bone (at protein level) (PubMed:26637977).
Involvement in Disease: Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Renal cell carcinoma papillary: A subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium.

Deafness, autosomal recessive, 97: A form of non-syndromic sensorineural hearing loss with prelingual onset. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Osteofibrous dysplasia: A congenital disorder of osteogenesis characterized by non-neoplastic, radiolucent lesions that affect the cortical bone immediately under the periosteum. It usually manifests as a painless swelling or anterior bowing of the long bones, most commonly the tibia and fibula.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.
Post-Translational Modification: Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.
Cellular Location: Membrane.
UniProt: P08581
Gene ID: 4233
Synonyms: AUTS9 Antibody
c met Antibody
D249 Antibody
DKFZp686H1252 Antibody
DKFZp762G052 Antibody
EC 2.1.1.56 Antibody
FLJ10005 Antibody
FLJ13213 Antibody
HCM Antibody
hcm1p Antibody
hCMT1 Antibody
HCMT1a Antibody
hCMT1c Antibody
Hepatocyte growth factor receptor Antibody
HGF Antibody
HGF receptor Antibody
HGF/SF receptor Antibody
HGFR Antibody
hMet Antibody
hypothetical protein KIAA0396 Antibody
KIAA0398 Antibody
MCES_HUMAN Antibody
Met (c-Met) Antibody
Met (c-Met) (phospho Y1003) Antibody
Met (c-Met) (phospho Y1230 + Y1234 + Y1235) Antibody
Met (c-Met) (phospho Y1234) Antibody
Met (c-Met) (phospho Y1349) Antibody
Met (c-Met) (phospho Y1356) Antibody
Met proto oncogene tyrosine kinase Antibody
MET proto oncogene, receptor tyrosine kinase Antibody
Met proto-oncogene Antibody
Met proto-oncogene (hepatocyte growth factor receptor) Antibody
Met protooncogene Antibody
Methionine Antibody
MET_HUMAN Antibody
Modulator of estrogen induced transcription Antibody
mRNA (guanine 7)methyltransferase Antibody
mRNA (guanine N(7)) methyltransferase Antibody
mRNA (guanine-N(7)-)-methyltransferase Antibody
mRNA cap guanine-N7 methyltransferase Antibody
mRNA cap methyltransferase Antibody
Oncogene MET Antibody
OTTHUMP00000162509 Antibody
Par4 Antibody
Proto-oncogene c-Met Antibody
RCCP2 Antibody
RG7MT1 Antibody
RNA (guanine 7) methyltransferase Antibody
RNA guanine 7 methyltransferase Antibody
Rnmt Antibody
SAFB like transcription modulator Antibody
Scatter factor receptor Antibody
SF receptor Antibody
SLTM Antibody
Tyrosine-protein kinase Met Antibody

Images
Western Blot - Anti-MET Antibody from ABclonal (A0040) - Antibody Supply Service
Western blot analysis of extracts of various cells, using MET antibody.

Product Code - A0040
Size Price Quantity
50µl £148
100µl £243
200µl £372

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