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Anti-Cyclin A Antibody

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ABclonal
A0034
Overview
Name: Anti-Cyclin A Antibody
Description: Rabbit polyclonal antibody to Cyclin A.
Applications: WB, IHC, FC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human CCNA2
Protein Length: 432
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.
Post-Translational Modification: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Cellular Location: Nucleus. Cytoplasm.

Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).
UniProt: P20248
Gene ID: 890

Images
Western Blot - Anti-Cyclin A Antibody from ABclonal (A0034) - Antibody Supply Service
Western blot analysis of extracts of K-562 cell line, using CCNA2 antibody.

Product Code - A0034
Size Price Quantity
100µl £243
200µl £372

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