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Anti-IgM Antibody

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Absea Biotechnology
Name: Anti-IgM Antibody
Description: Mouse monoclonal (KT38) antibody to IgM.
Applications: ELISA
Reactivity: Human
Immunogen: Recombinant human IgM.
Host: Mouse
Clonality: Monoclonal
Clone: KT38
Isotype: IgG1
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target (Information from UniProt)
Function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).
Involvement in Disease: Agammaglobulinemia 1, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Cellular Location: Secreted.

During differentiation, B-lymphocytes switch from expression of membrane-bound IgM to secretion of IgM.
UniProt: P01871
Synonyms: AGM1 Antibody
AI326936 Antibody
B cell associated molecule CD40 Antibody
B cell surface antigen CD40 Antibody
B cell-associated molecule Antibody
B-cell surface antigen CD40 Antibody
Bp50 Antibody
CD 40 Antibody
CD 40L Antibody
CD154 Antibody
CD40 Antibody
CD40 (phospho T254) Antibody
CD40 antigen Antibody
CD40 antigen (TNF receptor superfamily member 5) Antibody
CD40 antigen ligand Antibody
CD40 ligand Antibody
CD40 ligand, soluble form Antibody
CD40 molecule Antibody
CD40 molecule, TNF receptor superfamily member 5 Antibody
CD40 protein Antibody
CD40 type II isoform Antibody
CD40-L Antibody
CD40L Antibody
CD40L receptor Antibody
CD40LG Antibody
CD40L_HUMAN Antibody
CDw40 Antibody
Constant region of heavy chain of IgM Antibody
DKFZp686I15196 Antibody
DKFZp686I15212 Antibody
FLJ00385 Antibody
GP39 Antibody
hCD40L Antibody
heavy chain of IgM Antibody
Hepatitis B virus receptor binding protein Antibody
HIGM1 Antibody
Ig mu chain C region Antibody
Ig mu chain C region secreted form Antibody
Igh 6 Antibody
Igh-6 Antibody
IGHM Antibody
IgM heavy chain constant region Antibody
IMD3 Antibody
immunoglobulin heavy chain Antibody
Immunoglobulin heavy constant mu Antibody
Immunoglobulin mu chain Antibody
Imunoglobulin heavy chain Antibody
Imunoglobulin heavy chain constant region mu Antibody
Imunoglobulin heavy chain mu constant region Antibody
MGC104996 Antibody
MGC52291 Antibody
MGC9013 Antibody
Mouse IgM Antibody
MU Antibody
Nerve growth factor receptor related B lymphocyte activation molecule Antibody
OTTHUMP00000031699 Antibody
OTTHUMP00000031700 Antibody
p50 Antibody
T B cell activating molecule Antibody
T BAM Antibody
T-BAM Antibody
T-cell antigen Gp39 Antibody
TBAM Antibody
TNF receptor superfamily member 5 Antibody
TNF-related activation protein Antibody
TNFRSF5 Antibody
TNFSF5 Antibody
TNR5_HUMAN Antibody
TRAP Antibody
Tumor necrosis factor (ligand) superfamily member 5 Antibody
Tumor necrosis factor ligand superfamily member 5 Antibody
Tumor necrosis factor receptor superfamily , member 5 Antibody
Tumor necrosis factor receptor superfamily member 5 Antibody
Tumor necrosis factor receptor superfamily member 5 precursor Antibody
Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a Antibody
VH Antibody

Product Code - 000102A06
Size Price Quantity
100µg £178
200µg £259
1mg £682

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