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5HT1B Positive Control

Name: 5HT1B Positive Control
Applications: WB
Dilutions: Western Blot: 1:2,500-1:5,000
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Tissue Specificity: Predominantly expressed in striatum and Purkinje cells.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification: Phosphorylated.
Cellular Location: Cell membrane.
UniProt: P28334

Product Code - PC-5HT1B
Size Price Quantity
5 Applications £234

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