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5HT1A Positive Control

Name: 5HT1A Positive Control
Applications: WB
Dilutions: Western Blot: 1:2,500-1:5,000
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Tissue Specificity: Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
Cellular Location: Cell membrane.
UniProt: P19327
Synonyms: 5 HT 1A
5 HT receptor 1A
5 HT1A
5 HT1A receptor
5 hydroxytryptamine (serotonin) receptor 1A
5 hydroxytryptamine (serotonin) receptor 1A G protein coupled
5 hydroxytryptamine receptor 1A
5-hydroxytryptamine receptor 1A
5HT 1A
5HT 1A receptor
5HT receptor 1A
5HT1A Receptor
G 21
G protein coupled receptor
Gpcr 18
Guanine nucleotide binding regulatory protein-coupled receptor
Serotonin 1A receptor
Serotonin 5HT1A receptor
Serotonin receptor 1A

Product Code - PC-5HT1A
Size Price Quantity
5 Applications £234

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