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Anti-PDE4A Antibody

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FabGennix
PD4A-112AP
Details
Description: Rabbit polyclonal antibody to PDE4A
Category: Primary Antibodies
Applications: CM, ELISA, ICC, IF, IHC, IP, WB
Host: Rabbit
Clonality: Polyclonal
Reactivity: Human, Moose, Mouse, Rat
UniProt: P27815
Immunogen: Synthetic cyclic peptide corresponding to the C-terminal region of PDE4A. Common to all PDE4A proteins.
Concentration: 0 .5 µg/µl in antibody stabilization buffer
Synonyms: 5''-cyclic phosphodiesterase 4A
Background: Hydrolyzes the second messenger cAMP which is a key regulator of many important physiological processes.
Storage: -20⁰C for long term storage
Recommended Dilutions: Confocal Microscopy: 1:100-1:400; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:100-1:400; Immunofluorescence: 1:100-1:400; Immunohistochemistry: 1:100-1:400; Immunoprecipitation: 1:250; Western Blot: 1:1,000-1:2,500

Target (Information from UniProt)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Tissue Specificity: Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Post-Translational Modification: Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.
Cellular Location: Cytoplasm > Perinuclear region.

Images
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service

Product Code - PD4A-112AP
Size Price Quantity
100µg £475

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