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Anti-PDE4A Antibody

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FabGennix
PD4A-112AP
Overview
Name: Anti-PDE4A Antibody
Description: Rabbit polyclonal antibody to PDE4A
Applications: CM, ELISA, ICC, IF, IHC, IP, WB
Dilutions: Confocal Microscopy: 1:100-1:400; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:100-1:400; Immunofluorescence: 1:100-1:400; Immunohistochemistry: 1:100-1:400; Immunoprecipitation: 1:250; Western Blot: 1:1,000-1:2,500
Reactivity: Human, Moose, Mouse, Rat
Immunogen: Synthetic cyclic peptide corresponding to the C-terminal region of PDE4A. Common to all PDE4A proteins.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 0 .5 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Tissue Specificity: Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Post-Translational Modification: Phosphorylation by MAPKAPK2 its activation through PKA phosphorylation (By similarity). Phosphorylated at Ser-686 and Ser-688 when expressed in S.frugiperda cells. Isoform 2 and isoform 7 are activated by phosphorylation at Ser-119 and Ser-123 respectively by PKA.
Cellular Location: Cytoplasm > Perinuclear region.
UniProt: P27815
Synonyms: 5''-cyclic phosphodiesterase 4A Antibody
cAMP specific phosphodiesterase Antibody
cAMP-specific 3'' Antibody
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Antibody
DPDE2 Antibody
dunce like phosphodiesterase E2 Antibody
PDE 4A Antibody
PDE4 Antibody
PDE46 Antibody
PDE4A (phospho S) Antibody
PDE4A11 Antibody
PDE4A4 Antibody
PDE4A5 Antibody
PDE4A_HUMAN Antibody
PDE4B Antibody
PDE4C Antibody
PDE4D Antibody
Phosphodiesterase 4 Antibody
Phosphodiesterase 4A Antibody
phosphodiesterase 4A cAMP specific Antibody
Phosphodiesterase 4A, cAMP-specific (dunce Antibody
Phosphodiesterase 4B Antibody
Phosphodiesterase 4C Antibody
Phosphodiesterase 4D Antibody
phosphodiesterase E2 dunce homolog Antibody
Phosphodiesterase E2 dunce homolog, Drosophila Antibody
phosphodiesterase isozyme 4 Antibody
phosphodiesterase type 4A11 Antibody

Images
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service
Anti-PDE4A Antibody from FabGennix (PD4A-112AP) - Antibody Supply Service

Product Code - PD4A-112AP
Size Price Quantity
100µg £475

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