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Anti-LARP7 Antibody (Biotin)

FabGennix
LARP7.712-BIOTIN
Overview
Name: Anti-LARP7 Antibody (Biotin)
Description: Rabbit polyclonal antibody to LARP7 (Biotin)
Applications: ELISA, IMM, WB
Dilutions: DB: 1:4,000; DB: 1:4,000; ELISA: 1:4,000; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity: Human
Immunogen: Synthetic peptide taken within amino acid region 300-350 on human LARP7 protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Biotin
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Involvement in Disease: Alazami syndrome: A syndromic form of primordial dwarfism, a condition characterized by severe growth restriction that has its onset in utero, and results in short stature and undersize. ALAZS patients manifest severe intellectual disability and distinct facial features including malar hypoplasia, deep-set eyes, broad nose, short philtrum, and macrostomia. Some patients have non-specific and inconsistent skeletal findings, for example, scoliosis and mild epiphyseal changes in the proximal phalanges, but no frank dysplasia.
Cellular Location: Nucleus > Nucleoplasm.
UniProt: Q4G0J3
Synonyms: DKFZp564K112 Antibody
HDCMA18P Antibody
La related protein 7 Antibody
La ribonucleoprotein domain family member 7 Antibody
La-related protein 7 Antibody
LARP 7 Antibody
LARP7_HUMAN Antibody
MGC104360 Antibody
P TEFb interaction protein for 7SK stability Antibody
P-TEFb-interaction protein for 7SK stability Antibody
PIP7S Antibody

Product Code - LARP7.712-BIOTIN
Size Price Quantity
100µg £429

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