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Anti-LARP7 Antibody (Biotin)

FabGennix
LARP7.712-BIOTIN
Details
Description: Rabbit polyclonal antibody to LARP7 (Biotin)
Category: Primary Antibodies
Applications: ELISA, IMM, WB
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Reactivity: Human
UniProt: Q4G0J3
Immunogen: Synthetic peptide taken within amino acid region 300-350 on human LARP7 protein.
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Synonyms: HDCMA18P antibody
Background: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Storage: -20⁰C for long term storage
Accession No: AAI07710.2
Recommended Dilutions: DB: 1:4,000; DB: 1:4,000; ELISA: 1:4,000; Immunoprecipitation: 1:150; Western Blot: 1:500

Target (Information from UniProt)
Function: Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Involvement in Disease: Alazami syndrome: A syndromic form of primordial dwarfism, a condition characterized by severe growth restriction that has its onset in utero, and results in short stature and undersize. ALAZS patients manifest severe intellectual disability and distinct facial features including malar hypoplasia, deep-set eyes, broad nose, short philtrum, and macrostomia. Some patients have non-specific and inconsistent skeletal findings, for example, scoliosis and mild epiphyseal changes in the proximal phalanges, but no frank dysplasia.
Cellular Location: Nucleus > Nucleoplasm.

Product Code - LARP7.712-BIOTIN
Size Price Quantity
100µg £429

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