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Anti-CD163 Antibody (Biotin)

FabGennix
CD163.101-BIOTIN
Overview
Name: Anti-CD163 Antibody (Biotin)
Description: Rabbit polyclonal antibody to CD163 (Biotin)
Applications: ELISA, IF, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity: Human, Monkey
Immunogen: Synthetic peptide taken within amino acid region 600-650 on human CD163 protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target
Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Synonyms: C163A_HUMAN Antibody
CD 163 Antibody
CD163 antigen Antibody
CD163 molecule Antibody
Hemoglobin scavenger receptor Antibody
M130 Antibody
M130 antigen precursor Antibody
Macrophage associated antigen Antibody
MM130 Antibody
OTTHUMP00000238617 Antibody
OTTHUMP00000238618 Antibody
OTTHUMP00000238619 Antibody
OTTHUMP00000238620 Antibody
Scavenger receptor cysteine rich type 1 protein M130 Antibody
sCD163 Antibody
Soluble CD163 Antibody

Product Code - CD163.101-BIOTIN
Size Price Quantity
100µg £429

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