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Anti-ARHGEF7 Antibody (Biotin)

Name: Anti-ARHGEF7 Antibody (Biotin)
Description: Rabbit polyclonal antibody to ARHGEF7 (Biotin)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Biotin
Concentration: 0.59 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Post-Translational Modification: Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.
Cellular Location: Cell junction > Focal adhesion. Cell projection > Ruffle. Cytoplasm > Cell cortex. Cell projection > Lamellipodium.

Detected at cell adhesions. A small proportion is detected at focal adhesions.
UniProt: Q14155
Synonyms: ARHG7 Antibody
ARHG7_HUMAN Antibody
ARHGEF 7 Antibody
Beta pix Antibody
Beta-Pix Antibody
betaPix Antibody
betaPix-b Antibody
betaPix-c Antibody
Cool Antibody
COOL-1 Antibody
COOL1 Antibody
DKFZp686C12170 Antibody
DKFZp761K1021 Antibody
KIAA0142 Antibody
KIAA0412 Antibody
mKIAA0142 Antibody
Nbla10314 Antibody
P50 Antibody
P50BP Antibody
p85 Antibody
P85COOL1 Antibody
P85SPR Antibody
PAK interacting exchange factor beta Antibody
PAK-interacting exchange factor beta Antibody
PAK3 Antibody
Pak3bp Antibody
PIX Antibody
PIXB Antibody
Rho guanine nucleotide exchange factor (GEF) 7 Antibody
Rho guanine nucleotide exchange factor (GEF) 7b Antibody
Rho guanine nucleotide exchange factor (GEF7) Antibody
Rho guanine nucleotide exchange factor 7 Antibody
SH3 domain containing proline rich protein Antibody

Product Code - ARHGEF7-BIOTIN
Size Price Quantity
100µg £429

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