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Anti-ARHGEF7 Antibody (Biotin)

FabGennix
ARHGEF7-BIOTIN
Overview
Name: Anti-ARHGEF7 Antibody (Biotin)
Description: Rabbit polyclonal antibody to ARHGEF7 (Biotin)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Biotin
Concentration: 0.59 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Post-Translational Modification: Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.
Cellular Location: Cell junction > Focal adhesion. Cell projection > Ruffle. Cytoplasm > Cell cortex. Cell projection > Lamellipodium.

Detected at cell adhesions. A small proportion is detected at focal adhesions.
UniProt: Q14155
Synonyms: ARHG7 Antibody
ARHG7_HUMAN Antibody
ARHGEF 7 Antibody
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Product Code - ARHGEF7-BIOTIN
Size Price Quantity
100µg £429

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