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Anti-Phospho-Histone H3 Antibody (S10) (Biotin)

FabGennix
PHH3-BIOTIN
Overview
Name: Anti-Phospho-Histone H3 Antibody (S10) (Biotin)
Description: Rabbit polyclonal antibody to Phospho-Histone H3 (S10) (Biotin)
Applications: ELISA, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Monkey, Rat
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Biotin
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sequence Similarities: Belongs to the histone H3 family.
Post-Translational Modification: Acetylation is generally linked to gene activation. Acetylation on Lys-10 (H3K9ac) impairs methylation at Arg-9 (H3R8me2s). Acetylation on Lys-19 (H3K18ac) and Lys-24 (H3K24ac) favors methylation at Arg-18 (H3R17me). Acetylation at Lys-123 (H3K122ac) by EP300/p300 plays a central role in chromatin structure: localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability.
Cellular Location: Nucleus. Chromosome.
UniProt: P68431

Product Code - PHH3-BIOTIN
Size Price Quantity
100µg £475

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