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Anti-Phospho-Chimaerin beta 2 Antibody (Biotin)

FabGennix
PCHIM-BIOTIN
Overview
Name: Anti-Phospho-Chimaerin beta 2 Antibody (Biotin)
Description: Rabbit polyclonal antibody to Phospho-Chimaerin beta 2 (Biotin)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 0; Immunohistochemistry: 0; Immunoprecipitation: 0; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Phosphorylated synthetic peptide corresponding to unique amino acid sequence on beta 2 Chimaerin protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Biotin
Concentration: 0.58-0.63 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Tissue Specificity: In neurons in brain regions that are involved in learning and memory processes.
Involvement in Disease: Duane retraction syndrome 2: A form of Duane retraction syndrome, a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction or both, narrowing of the palpebral fissure, and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
Post-Translational Modification: Phosphorylated. Phosphorylation is EPHA4 kinase activity-dependent (By similarity).
UniProt: P15882

Product Code - PCHIM-BIOTIN
Size Price Quantity
100µg £475

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