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Anti-nmt55 / NONO / p54nrb Antibody

FabGennix
NONO-101AP
Overview
Name: Anti-nmt55 / NONO / p54nrb Antibody
Description: Rabbit polyclonal antibody to nmt55 / NONO / p54nrb
Applications: ELISA, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 200-250 on human NonO protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript.
Tissue Specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Also found in a number of breast tumor cell lines.
Involvement in Disease: Mental retardation, X-linked, syndromic, 34: A mental retardation syndrome characterized by intellectual deficit, delayed psychomotor development, poor speech, and dysmorphic features. Mental retardation is defined by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
Post-Translational Modification: The N-terminus is blocked.
Cellular Location: Nucleus. Nucleus > Nucleolus. Nucleus speckle.

Detected in punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles.
UniProt: Q15233
Synonyms: 52 kDa subunit Antibody
54 kDa nuclear RNA and DNA binding protein Antibody
54 kDa nuclear RNA- and DNA-binding protein Antibody
55 kDa nuclear protein Antibody
DNA binding p52/p100 complex 52 kDa subunit Antibody
DNA-binding p52/p100 complex Antibody
NMT 55 Antibody
nmt55 / p54nrb Antibody
Non Pou domain containing octamer (ATGCAAAT) binding protein Antibody
Non POU domain containing octamer binding Antibody
Non POU domain containing octamer binding protein Antibody
Non-POU domain-containing octamer-binding protein Antibody
Nono Antibody
NonO protein Antibody
NONO_HUMAN Antibody
NRB Antibody
NRB 54 Antibody
NRB54 Antibody
Nuclear RNA binding protein 54kD Antibody
P54 Antibody
p54(nrb) Antibody
p54nrb Antibody
PPP1R114 Antibody
Protein phosphatase 1 regulatory subunit 114 Antibody

Images
Anti-nmt55 / NONO / p54nrb Antibody from FabGennix (NONO-101AP) - Antibody Supply Service
Anti-nmt55 / NONO / p54nrb Antibody from FabGennix (NONO-101AP) - Antibody Supply Service

Product Code - NONO-101AP
Size Price Quantity
100µg £372

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