Anti-Glutamate Receptor 1 Antibody
|Description:||Rabbit polyclonal antibody to Glutamate Receptor 1|
|Immunogen:||Synthetic peptide taken within amino acid reigon 850-950.|
|Concentration:||0.64-0.72 µg/µl in antibody stabilization buffer|
|Synonyms:||AMPA 1 antibody|
|Background:||L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|
|Storage:||-20⁰C for long term storage|
|Recommended Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500|
Target (Information from UniProt)
|Function:||Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.|
|Tissue Specificity:||Widely expressed in brain.|
|Sequence Similarities:||Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.|
|Post-Translational Modification:||Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).|
|Cellular Location:||Cell membrane. Endoplasmic reticulum membrane. Cell junction > Synapse > Postsynaptic cell membrane. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density. Cell projection > Dendrite. Cell projection > Dendritic spine.
Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.