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Anti-Glutamate Receptor 1 Antibody

FabGennix
GLUR1-101AP
Details
Description: Rabbit polyclonal antibody to Glutamate Receptor 1
Category: Primary Antibodies
Applications: ELISA, WB
Host: Rabbit
Clonality: Polyclonal
Reactivity: Human
UniProt: P42261
Immunogen: Synthetic peptide taken within amino acid reigon 850-950.
Concentration: 0.64-0.72 µg/µl in antibody stabilization buffer
Synonyms: AMPA 1 antibody
Background: L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.
Storage: -20⁰C for long term storage
Accession No: CAA41491
Recommended Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500

Target (Information from UniProt)
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Tissue Specificity: Widely expressed in brain.
Sequence Similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA1 subfamily.
Post-Translational Modification: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Cellular Location: Cell membrane. Endoplasmic reticulum membrane. Cell junction > Synapse > Postsynaptic cell membrane. Cell junction > Synapse > Postsynaptic cell membrane > Postsynaptic density. Cell projection > Dendrite. Cell projection > Dendritic spine.

Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

Images
Anti-Glutamate Receptor 1 Antibody from FabGennix (GLUR1-101AP) - Antibody Supply Service

Product Code - GLUR1-101AP
Size Price Quantity
100µg £372

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