Anti-Syndecan-1 Antibody (FITC)
|Description:||Rabbit polyclonal antibody to Syndecan-1 (FITC)|
|Reactivity:||Human, Mouse, Rat|
|Immunogen:||N-epitope synthetic peptide taken within amino acid region 1-100 on human Syndecan-1 protein.|
|Concentration:||0.55-0.61 µg/µl in antibody stabilization buffer|
|Synonyms:||CD 138 antibody|
|Background:||Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.|
|Storage:||-20⁰C for long term storage|
|Recommended Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500|
Target (Information from UniProt)
|Function:||Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).|
|Sequence Similarities:||Belongs to the syndecan proteoglycan family.|
|Post-Translational Modification:||Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.|
|Cellular Location:||Membrane. Secreted. Secreted > Exosome.
Shedding of the ectodomain produces a soluble form.