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Anti-Phospho-TICAM2 Antibody (FITC)

FabGennix
PTRAM-FITC
Overview
Name: Anti-Phospho-TICAM2 Antibody (FITC)
Description: Rabbit polyclonal antibody to Phospho-TICAM2 (FITC)
Applications: ELISA, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500-1:750
Reactivity: Human, Mouse, Rat
Immunogen: Phosphorylated synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: FITC
Concentration: 0.50-0.75 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Tissue Specificity: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
Post-Translational Modification: Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
Cellular Location: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane.

Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.
UniProt: Q86XR7

Product Code - PTRAM-FITC
Size Price Quantity
100µg £475

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