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Anti-Phospho-KIRREL Antibody (FITC)

Name: Anti-Phospho-KIRREL Antibody (FITC)
Description: Rabbit polyclonal antibody to Phospho-KIRREL (FITC)
Applications: CM, ELISA, ICC, IF, IHC, IP, WB
Dilutions: Confocal Microscopy: 1:250; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:250; Western Blot: 1:250
Reactivity: Chicken, Human, Mouse, Rat, Zebra Fish
Immunogen: Phosphorylated synthetic peptide with phospo tyrosine 737 and 738 on mouse Kin of IRRE-like protein 1.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: FITC
Concentration: 0.45-0.65 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
Tissue Specificity: Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
Sequence Similarities: Belongs to the immunoglobulin superfamily.
Post-Translational Modification: Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding (By similarity).
Cellular Location: Cell membrane.

Predominantly located at podocyte slit diaphragm.
UniProt: Q80W68

Product Code - PNEPH-FITC
Size Price Quantity
100µg £475

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