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Anti-Visfatin Antibody (Biotin)

FabGennix
VSFTN.c-BIOTIN
Overview
Name: Anti-Visfatin Antibody (Biotin)
Description: Rabbit polyclonal antibody to Visfatin (Biotin)
Applications: ELISA, IHC, IP, WB
Dilutions: DB: 1:4,000; DB: 1:4,000; ELISA: 1:4,000; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity: Human, Rat
Immunogen: C-epitope synthetic peptide taken within amino acid region 400-490 on human Visfatin protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.68-0.70 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).
Tissue Specificity: Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Sequence Similarities: Belongs to the NAPRTase family.
Cellular Location: Nucleus. Cytoplasm. Secreted.

Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.
UniProt: P43490
Synonyms: 1110035O14Rik Antibody
AI314458 Antibody
AI480535 Antibody
DKFZP666B131 Antibody
EC 2.4.2.12 Antibody
MGC117256 Antibody
NAmPRTase Antibody
Nampt Antibody
NAMPT_HUMAN Antibody
Nicotinamide phosphoribosyltransferase Antibody
PBEF Antibody
PBEF 1 Antibody
PBEF1 Antibody
Pre B cell colony enhancing factor Antibody
Pre B cell colony enhancing factor 1 Antibody
Pre B cell enhancing factor Antibody
Pre-B cell-enhancing factor Antibody
Pre-B-cell colony-enhancing factor 1 Antibody
VF Antibody
Visfatin [14A5] Antibody

Product Code - VSFTN.c-BIOTIN
Size Price Quantity
100µg £429

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