Anti-Phospho-trp Antibody (Biotin)
|Description:||Rabbit polyclonal antibody to Phospho-trp (Biotin)|
|Immunogen:||Phosphorylated synthetic peptide corresponding to unique amino acid sequences on D. melanogaster Transient Receptor Potential isoform A protein.|
|Concentration:||0.6 µg/µl in antibody stabilization buffer|
|Background:||A light-sensitive calcium channel that is required for inositide-mediated Ca2+ entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca2+ influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling.|
|Storage:||-20⁰C for long term storage|
|Recommended Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:10,000|
Target (Information from UniProt)
|Function:||A light-sensitive calcium channel that is required for inositide-mediated Ca(2+) entry in the retina during phospholipase C (PLC)-mediated phototransduction. Ca(2+) influx may then feed back and inhibit PLC, thereby facilitating phosphatidylinositol 4,5 bisphosphate (PIP2) recycling. Trp and trpl act together in the light response, though it is unclear whether as heteromultimers or as distinct units, and are activated by fatty acids and metabolic stress. Also required for olfactory adaptation and may be involved in olfactory system development.|
|Tissue Specificity:||Expressed predominantly in the rhabdomeres of photoreceptor cells. Expressed in the third antennal segment and in the olfactory segment at approximately 70 hours after puparium formation during antennal development.|
|Sequence Similarities:||Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.|
|Post-Translational Modification:||Phosphorylated by inaC.|
|Cellular Location:||Cell membrane.
Localized on plasma membrane loops found at the base of the rhabdomere, in close proximity to the calcium stores.