Anti-PDE10A12 Antibody (Biotin)
|Name:||Anti-PDE10A12 Antibody (Biotin)|
|Description:||Rabbit polyclonal antibody to PDE10A12 (Biotin)|
|Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500|
|Immunogen:||Synthetic peptide taken within amino acid region 50-120 on PDE10A12 protein.|
|Concentration:||0.67-0.75 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
Target (Information from UniProt)
|Function:||Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.|
|Tissue Specificity:||Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.|
|Involvement in Disease:||Dyskinesia, limb and orofacial, infantile-onset: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.
Striatal degeneration, autosomal dominant 2: An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
|Sequence Similarities:||Belongs to the cyclic nucleotide phosphodiesterase family.|
|Post-Translational Modification:||Isoform PDE10A2: Phosphorylated on Thr-16.|
Located mostly to soluble cellular fractions.