Anti-KIRREL Antibody (Biotin)
|Description:||Rabbit polyclonal antibody to KIRREL (Biotin)|
|Applications:||CM, ELISA, ICC, IF, IHC, IP, WB|
|Concentration:||0.45-0.65 µg/µl in antibody stabilization buffer|
|Background:||Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.|
|Storage:||-20⁰C for long term storage|
|Recommended Dilutions:||Confocal Microscopy: 1:250; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:250; Western Blot: 1:250|
Target (Information from UniProt)
|Function:||Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.|
|Tissue Specificity:||Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.|
|Sequence Similarities:||Belongs to the immunoglobulin superfamily.|
|Post-Translational Modification:||Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding (By similarity).|
|Cellular Location:||Cell membrane.
Predominantly located at podocyte slit diaphragm.