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Anti-Aquaporin 3 Antibody (Biotin)

Description: Rabbit polyclonal antibody to Aquaporin 3 (Biotin)
Category: Primary Antibodies
Applications: ELISA, ICC, IF, IHC, IP, WB
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Reactivity: Bovine, Human, Sheep, Mouse, Rat
UniProt: P47862
Immunogen: Synthetic peptide taken within amino acid region 200-250 on human Aquaporin 3 protein.
Concentration: 0.50-0.57 µg/µl in antibody stabilization buffer
Synonyms: AQP 3 antibody
Background: Promotes glycerol permeability and water transport across cell membranes.  Plays important role in regulating stratum corneum and epidermal glyceral content.  Involved in skin hydration, wound healing and tumorigenesis.
Storage: -20⁰C for long term storage
Accession No: CAG46822
Recommended Dilutions: ELISA: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:100; Immunofluorescence: 1:100; Immunohistochemistry: 1:100; Immunoprecipitation: 1:200; Western Blot: 1:500

Target (Information from UniProt)
Function: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
Tissue Specificity: Renal medulla and colon. Predominantly in the inner medulla.
Sequence Similarities: Belongs to the MIP/aquaporin (TC 1.A.8) family.
Cellular Location: Membrane.

Product Code - AQP3-BIOTIN
Size Price Quantity
100µg £429

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