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Anti-Aquaporin 2 Antibody (Biotin)

FabGennix
AQP2-BIOTIN
Overview
Name: Anti-Aquaporin 2 Antibody (Biotin)
Description: Rabbit polyclonal antibody to Aquaporin 2 (Biotin)
Applications: ELISA, IP, WB
Dilutions: ELISA: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:200; Western Blot: 1:500
Reactivity: Bovine, Human, Sheep, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 200-250 on human Aquaporin 2 protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Biotin
Concentration: 0.50-0.62 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
Tissue Specificity: Expressed in renal collecting tubules.
Sequence Similarities: Belongs to the MIP/aquaporin (TC 1.A.8) family.
Post-Translational Modification: Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent (By similarity).
Cellular Location: Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus > trans-Golgi network membrane.

Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
UniProt: P34080
Synonyms: ADH water channel Antibody
AQP 2 Antibody
AQP CD Antibody
AQP-2 Antibody
AQP-CD Antibody
AQP2 Antibody
AQP2_HUMAN Antibody
AQPCD Antibody
Aquaporin 2 collecting duct Antibody
Aquaporin CD Antibody
Aquaporin-2 Antibody
Aquaporin-CD Antibody
Aquaporin2 Antibody
Aquaporine 2 Antibody
Collecting duct water channel protein Antibody
MGC34501 Antibody
Water channel aquaporin 2 Antibody
Water channel protein for renal collecting duct Antibody
WCH CD Antibody
WCH-CD Antibody
WCHCD Antibody

Product Code - AQP2-BIOTIN
Size Price Quantity
100µg £429

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