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Anti-Phospho-PDE4D ERK site Antibody

FabGennix
PPD4-450AP
Overview
Name: Anti-Phospho-PDE4D ERK site Antibody
Description: Rabbit polyclonal antibody to Phospho-PDE4D ERK site
Applications: ELISA, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Phosphorylated synthetic peptide selective for PDE4D ERK site taken within amino acid ergion 550-600 on human PDE4D8 protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 0.57 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Tissue Specificity: Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Involvement in Disease: Acrodysostosis 2, with or without hormone resistance: A pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.
Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Post-Translational Modification: Long isoforms that share a conserved PKA phosphorylation site in the N-terminus are activated by PKA through phosphorylation (By similarity). Isoform 3 and isoform 7 are activated by phosphorylation (in vitro), but not isoform 6. Isoform N3 and isoform 12 are phosphorylated on Ser-49, Ser-51, Ser-55 and Ser-59.
Cellular Location: Apical cell membrane. Cytoplasm. Membrane. Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome.

Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
UniProt: Q08499

Product Code - PPD4-450AP
Size Price Quantity
100µg £429

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