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Anti-Phospho-PDE10A Antibody (FITC)

FabGennix
PPD10A-FITC
Overview
Name: Anti-Phospho-PDE10A Antibody (FITC)
Description: Rabbit polyclonal antibody to Phospho-PDE10A (FITC)
Applications: ELISA, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:200; Western Blot: 1:500
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Phosphorylated synthetic MAP common to all PDE10A variants. Taken within amino acid region 1-50 on human PDE10A protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: FITC
Concentration: 0.7 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Tissue Specificity: Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Involvement in Disease: Dyskinesia, limb and orofacial, infantile-onset: An autosomal recessive, early-onset hyperkinetic movement disorder characterized by axial hypotonia, dyskinesia of the limbs and trunk, orofacial dyskinesia, drooling, and dysarthria. The severity of the hyperkinesis is variable.

Striatal degeneration, autosomal dominant 2: An autosomal dominant disorder characterized by striatal degeneration and dysfunction of basal ganglia, resulting in hyperkinesis.
Sequence Similarities: Belongs to the cyclic nucleotide phosphodiesterase family.
Post-Translational Modification: Isoform PDE10A2: Phosphorylated on Thr-16.
Cellular Location: Cytoplasm.

Located mostly to soluble cellular fractions.
UniProt: Q9Y233

Product Code - PPD10A-FITC
Size Price Quantity
100µg £475

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