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Anti-GPCR GPR75 Antibody (FITC)

FabGennix
GPCR75.112-FITC
Details
Description: Rabbit polyclonal antibody to GPCR GPR75 (FITC)
Category: Primary Antibodies
Applications: CM, ELISA, ICC, IHC, IF, IP, WB
Host: Rabbit
Clonality: Polyclonal
Conjugate: FITC
Reactivity: Human, Mouse, Rat
UniProt: O95800
Immunogen: Synthetic peptide taken within amino acid reigon 25-75 on human G protein-coupled receptor 75 protein.
Concentration: 0.75-1.25 µg/µl in antibody stabilization buffer
Synonyms: G protein coupled receptor 75 antibody
Background: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES,may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Storage: -20⁰C for long term storage
Accession No: AAH67475.1
Recommended Dilutions: Confocal Microscopy: 1:250; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:250; Western Blot: 1:500

Target (Information from UniProt)
Function: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Tissue Specificity: Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Cellular Location: Cell membrane.

Product Code - GPCR75.112-FITC
Size Price Quantity
100µg £429

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