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Anti-alpha Actinin 4 Antibody (FITC)

FabGennix
ACTN4-FITC
Details
Description: Rabbit polyclonal antibody to alpha Actinin 4 (FITC)
Category: Primary Antibodies
Applications: ELISA, IP, WB
Host: Rabbit
Clonality: Polyclonal
Conjugate: FITC
Reactivity: Human, Monkey, Mouse, Rat
UniProt: O43707
Immunogen: Synthetic peptide taken within amino acid region 140-190 on human Alpha Actinin 4 protein.
Concentration: 0.62 µg/µl in antibody stabilization buffer
Synonyms: F actin cross linking protein antibody
Background: F-actin cross-linking protein that anchors variety of intracellular structures. Bundling protein involved in vesicular trafficking via its association with the CART complex.
Storage: -20⁰C for long term storage
Accession No: NP_004915
Recommended Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500

Target (Information from UniProt)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).
Tissue Specificity: Widely expressed.
Involvement in Disease: Focal segmental glomerulosclerosis 1: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Sequence Similarities: Belongs to the alpha-actinin family.
Cellular Location: Nucleus. Cytoplasm. Cell junction.

Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7).

Product Code - ACTN4-FITC
Size Price Quantity
100µg £429

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