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Anti-alpha Actinin 4 Antibody (FITC)

FabGennix
ACTN4-FITC
Overview
Name: Anti-alpha Actinin 4 Antibody (FITC)
Description: Rabbit polyclonal antibody to alpha Actinin 4 (FITC)
Applications: ELISA, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 140-190 on human Alpha Actinin 4 protein.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: FITC
Concentration: 0.62 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).
Tissue Specificity: Widely expressed.
Involvement in Disease: Focal segmental glomerulosclerosis 1: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
Sequence Similarities: Belongs to the alpha-actinin family.
Cellular Location: Nucleus. Cytoplasm. Cell junction.

Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC-2, and bladder cancer KU-7).
UniProt: O43707
Synonyms: actinin 4 Antibody
Actinin alpha 4 Antibody
actinin4 Antibody
ACTN 4 Antibody
ACTN4 Antibody
ACTN4_HUMAN Antibody
Alpha-actinin-4 Antibody
DKFZp686K23158 Antibody
F actin cross linking protein Antibody
F-actin cross-linking protein Antibody
Focal segmental glomerulosclerosis 1 Antibody
FSGS Antibody
FSGS 1 Antibody
FSGS1 Antibody
Non muscle alpha actinin 4 Antibody
Non-muscle alpha-actinin 4 Antibody

Product Code - ACTN4-FITC
Size Price Quantity
100µg £429

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