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Anti-RIP140 Antibody (Biotin)

FabGennix
RIP140.101-BIOTIN
Overview
Name: Anti-RIP140 Antibody (Biotin)
Description: Rabbit polyclonal antibody to RIP140 (Biotin)
Applications: CM, ELISA, ICC, IHC, IF, IP, WB
Dilutions: Confocal Microscopy: 1:250; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:250; Immunofluorescence: 1:250; Immunohistochemistry: 1:250; Immunoprecipitation: 1:200; Western Blot: 1:1,000
Reactivity: Chicken, Human, Monkey, Rat
Immunogen: Synthetic peptide taken within amino acid region 50-100 on mouse receptor interacting protein 140.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0. 60 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.
Tissue Specificity: Expressed in the embryonic placenta. In the adult, expression is strong in the testis and brain. Also expressed at a high level in the white adipose tissue. Expressed constantly but at a weaker level in the adult heart, lung, stomach and kidney. Expressed moderately in the skeletal muscle. Expressed at a low level in the adult spleen, liver and brown adipose tissue. Expressed in the ovary at a high level in granulosa cells and at a lower level in the thecal and interstitial compartments.
Post-Translational Modification: Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH (By similarity). Acetylation regulates its nuclear translocation and corepressive activity.
Cellular Location: Nucleus.
UniProt: Q8CBD1
Synonyms: NRIP 1 Antibody
NRIP1 Antibody
NRIP1_HUMAN Antibody
Nuclear factor RIP 140 Antibody
Nuclear factor RIP140 Antibody
Nuclear receptor interacting protein 1 Antibody
Nuclear receptor-interacting protein 1 Antibody
Receptor interacting protein 140 Antibody
Receptor-interacting protein 140 Antibody
RIP 140 Antibody

Product Code - RIP140.101-BIOTIN
Size Price Quantity
100µg £429

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