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Anti-FXIIIA Antibody (Biotin)

FabGennix
FXIIIA.121-BIOTIN
Details
Description: Rabbit polyclonal antibody to FXIIIA (Biotin)
Category: Primary Antibodies
Applications: CM, ELISA, ICC, IHC, IF, IP, WB
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Reactivity: Human
UniProt: P00488
Immunogen: Multi-epitope synthetic peptides were used: amino acid range 1-50 and 700-750. A mixture of synthetic peptides used for FXIIIA-101AP and FXIIIA-112AP.
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Synonyms: Coagulation factor XIII A chain antibody
Background: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Storage: -20⁰C for long term storage
Accession No: AAA52415.1
Recommended Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:200; Immunofluorescence: 1:200; Immunohistochemistry: 1:200; Immunoprecipitation: 1:150; Western Blot: 1:500

Target (Information from UniProt)
Function: Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Involvement in Disease: Factor XIII subunit A deficiency: An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
Sequence Similarities: Belongs to the transglutaminase superfamily. Transglutaminase family.
Post-Translational Modification: The activation peptide is released by thrombin.
Cellular Location: Cytoplasm. Secreted.

Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

Product Code - FXIIIA.121-BIOTIN
Size Price Quantity
100µg £429

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