Anti-Human Lactoferrin Antibody (FITC)
|Description:||Rabbit polyclonal antibody to Human Lactoferrin (FITC)|
|Applications:||CM, ELISA, ICC, IF, IHC, IP, WB|
|Concentration:||0.8 µg/µl in antibody stabilization buffer|
|Background:||Iron binding transport proteins which bind two Fe3+ ions in association with the binding of an anion usually bicarbonate. Binds to bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection.|
|Storage:||-20⁰C for long term storage|
|Accession No:||GeneBank: AAA59511|
|Recommended Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:200; Immunofluorescence: 1:200; Immunohistochemistry: 1:200; Immunoprecipitation: 1:200; Western Blot: 1:500|
Target (Information from UniProt)
|Function:||Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.|
|Tissue Specificity:||High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.|
|Sequence Similarities:||Belongs to the transferrin family.|
|Post-Translational Modification:||Isoform DeltaLf: Ubiquitinated at Lys-379 and Lys-391.|
|Cellular Location:||Secreted. Cytoplasmic granule.
Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.