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Anti-TMEM16A Antibody (Biotin)

FabGennix
TMEM16.112-BIOTIN
Details
Description: Rabbit polyclonal antibody to TMEM16A (Biotin)
Category: Primary Antibodies
Applications: ELISA, IMM, WB
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Reactivity: Human
UniProt: Q5XXA6
Immunogen: Synthetic peptide taken within amino acid region 900-950 on human Transmembrane protein 16A.
Concentration: 0 .50 µg/µl in antibody stabilization buffer
Synonyms: ANO 1 antibody
Background: Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Storage: -20⁰C for long term storage
Recommended Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:200; Western Blot: 1:500

Target (Information from UniProt)
Function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Tissue Specificity: Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.
Sequence Similarities: Belongs to the anoctamin family.
Cellular Location: Cell membrane. Cytoplasm.

Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.

Product Code - TMEM16.112-BIOTIN
Size Price Quantity
100µg £429

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