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Anti-TMEM16A Antibody (Biotin)

FabGennix
TMEM16.101-BIOTIN
Overview
Name: Anti-TMEM16A Antibody (Biotin)
Description: Rabbit polyclonal antibody to TMEM16A (Biotin)
Applications: ELISA, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:200; Western Blot: 1:500
Reactivity: Monkey, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region on 70-120 on mouse Transmembrane Protein 16A.
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Biotin
Concentration: 0 .50 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Tissue Specificity: Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.
Sequence Similarities: Belongs to the anoctamin family.
Cellular Location: Cell membrane. Cytoplasm.

Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors.
UniProt: Q8BHY3
Synonyms: ANO 1 Antibody
ANO1 Antibody
ANO1_HUMAN Antibody
Anoctamin 1 Antibody
Anoctamin 1 calcium activated chloride channel Antibody
Anoctamin-1 Antibody
Anoctamin1 Antibody
Ca2+ activated Cl- channel Antibody
Calcium Activated Chloride Channel Antibody
Discovered on gastrointestinal stromal tumors protein 1 Antibody
DOG 1 Antibody
FLJ10261 Antibody
Membrane protein Antibody
Oral cancer overexpressed 2 Antibody
Oral cancer overexpressed protein 2 Antibody
ORAOV 2 Antibody
ORAOV2 Antibody
TAOS 2 Antibody
TAOS2 Antibody
TMEM 16A Antibody
Transmembrane protein 16A Antibody
Transmembrane protein 16A (eight membrane spanning domains) Antibody
Tumor amplified and overexpressed sequence 2 Antibody
Tumor-amplified and overexpressed sequence 2 Antibody

Product Code - TMEM16.101-BIOTIN
Size Price Quantity
100µg £429

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