Anti-Phospho-JAK1 Antibody (Biotin)
|Name:||Anti-Phospho-JAK1 Antibody (Biotin)|
|Description:||Rabbit polyclonal antibody to Phospho-JAK1 (Biotin)|
|Applications:||ELISA, IHC, IP, WB|
|Dilutions:||ELISA: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Western Blot: 1:500|
|Reactivity:||Human, Mouse, Rat|
|Immunogen:||Synthetic peptide taken within amino acid region 1000-1050 on human JAK1 protein. Phosphorylated 1034 & 1035 tyrosine residues.|
|Concentration:||0.5 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
Target (Information from UniProt)
|Function:||Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).|
|Tissue Specificity:||Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.|
|Sequence Similarities:||Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|
|Post-Translational Modification:||Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).|
|Cellular Location:||Endomembrane system.
Wholly intracellular, possibly membrane associated.