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Anti-Phospho-JAK1 Antibody (Biotin)

FabGennix
PJAK1-BIOTIN
Overview
Name: Anti-Phospho-JAK1 Antibody (Biotin)
Description: Rabbit polyclonal antibody to Phospho-JAK1 (Biotin)
Applications: ELISA, IHC, IP, WB
Dilutions: ELISA: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 1000-1050 on human JAK1 protein. Phosphorylated 1034 & 1035 tyrosine residues.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.5 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).
Tissue Specificity: Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Post-Translational Modification: Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).
Cellular Location: Endomembrane system.

Wholly intracellular, possibly membrane associated.
UniProt: P23458

Product Code - PJAK1-BIOTIN
Size Price Quantity
100µg £429

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