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Anti-LIM kinase 2 Antibody (Biotin)

Name: Anti-LIM kinase 2 Antibody (Biotin)
Description: Rabbit polyclonal antibody to LIM kinase 2 (Biotin)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 570-638 on human LIMK2 protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.55-0.75 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Tissue Specificity: Overexpressed in several esophageal squamous cell carcinomas (ESCs).
Sequence Similarities: Belongs to the JHDM3 histone demethylase family.
Cellular Location: Nucleus.
UniProt: Q9H3R0
Synonyms: LIM domain kinase 2 Antibody
LIMK 2 Antibody
LIMK-2 Antibody
Limk2 Antibody
LIMK2_HUMAN Antibody

Product Code - LIMK2-BIOTIN
Size Price Quantity
100µg £429

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