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Anti-GPCR GPR43 Antibody (Biotin)

FabGennix
FFAR2.2-BIOTIN
Overview
Name: Anti-GPCR GPR43 Antibody (Biotin)
Description: Rabbit polyclonal antibody to GPCR GPR43 (Biotin)
Applications: DB, ELISA, IHC, IP, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Immunoprecipitation: 1:150; Immunoprecipitation: 1:150; Western Blot: 1:500
Reactivity: Human, Monkey
Immunogen: Synthetic peptide taken within amino acid region 280-330 on human free fatty acid receptor 2 protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Biotin
Concentration: 0.58-0.59 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).
Tissue Specificity: Expressed at relatively high levels in peripheral blood leukocytes and, to lesser extent, in spleen.
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Cellular Location: Cell membrane.
UniProt: O15552
Synonyms: FFA2R Antibody
Ffar2 Antibody
FFAR2_HUMAN Antibody
free fatty acid activated receptor 2 Antibody
Free fatty acid receptor 2 Antibody
G protein coupled receptor 43 Antibody
G protein-coupled receptor 43 Antibody
G-protein coupled receptor 43 Antibody
GPR 43 Antibody
GPR43 Antibody

Product Code - FFAR2.2-BIOTIN
Size Price Quantity
100µg £429

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