Anti-Sodium / Hydrogen Exchanger 3 Antibody (FITC)
|Name:||Anti-Sodium / Hydrogen Exchanger 3 Antibody (FITC)|
|Description:||Rabbit polyclonal antibody to Sodium / Hydrogen Exchanger 3 (FITC)|
|Dilutions:||DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500|
|Reactivity:||Human, Monkey, Mouse, Rat|
|Immunogen:||Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein.|
|Concentration:||0.68 µg/µl in antibody stabilization buffer|
|Storage:||-20⁰C for long term storage|
Target (Information from UniProt)
|Function:||Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.|
|Involvement in Disease:||Diarrhea 8, secretory sodium, congenital: A disease characterized by watery secretory diarrhea with prenatal onset, prominent abdominal distension after birth due to dilated fluid-filled loops of intestine, elevated fecal sodium concentrations and low urinary sodium concentrations.|
|Sequence Similarities:||Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|
|Post-Translational Modification:||Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.|
|Cellular Location:||Apical cell membrane.
In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity).