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Anti-Sodium / Hydrogen Exchanger 3 Antibody (FITC)

Name: Anti-Sodium / Hydrogen Exchanger 3 Antibody (FITC)
Description: Rabbit polyclonal antibody to Sodium / Hydrogen Exchanger 3 (FITC)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:500
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: FITC
Concentration: 0.68 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target (Information from UniProt)
Function: Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient (PubMed:26358773). Plays an important role in signal transduction.
Involvement in Disease: Diarrhea 8, secretory sodium, congenital: A disease characterized by watery secretory diarrhea with prenatal onset, prominent abdominal distension after birth due to dilated fluid-filled loops of intestine, elevated fecal sodium concentrations and low urinary sodium concentrations.
Sequence Similarities: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Post-Translational Modification: Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane.
Cellular Location: Apical cell membrane.

In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity).
UniProt: P48764

Product Code - SLC9A3-FITC
Size Price Quantity
100µg £429

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