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Anti-Myd88 (Phospho-Tyr257) Antibody

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Signalway Antibody
12764
Overview
Name: Anti-Myd88 (Phospho-Tyr257) Antibody
Description: Rabbit Polycolonal antibody to Myd88 (Phospho-Tyr257)
Specificity: Myd88 (Phospho-Tyr257) Antibody detects endogenous levels of Myd88 only when phosphorylated at Tyr257
Applications: WB
Reactivity: Human, Mouse, Rat
Immunogen: A synthesized peptide derived from human Myd88 (Phospho-Tyr257)
Host: Rabbit
Clonality: Polyclonal
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C

Target (Information from UniProt)
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Tissue Specificity: Ubiquitous.
Involvement in Disease: MYD88 deficiency: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.
Cellular Location: Cytoplasm.
UniProt: Q99836
Gene ID: 4615
Synonyms: Mutant myeloid differentiation primary response 88 Antibody
MYD 88 Antibody
MYD88D Antibody
MYD88_HUMAN Antibody
Myeloid differentiation marker 88 Antibody
Myeloid differentiation primary response 88 Antibody
Myeloid differentiation primary response gene Antibody
Myeloid differentiation primary response gene (88) Antibody
Myeloid differentiation primary response gene 88 Antibody
Myeloid differentiation primary response protein MyD88 Antibody
OTTHUMP00000161718 Antibody
OTTHUMP00000208595 Antibody
OTTHUMP00000209058 Antibody
OTTHUMP00000209059 Antibody
OTTHUMP00000209060 Antibody

Images
Western blot - Myd88 (Phospho-Tyr257) Antibody from Signalway Antibody (12764) - Antibody Supply Service
Western blot analysis Myd88 (Phospho-Tyr257) using nocodazole treated HeLa whole cell lysates

Product Code - 12764
Size Price Quantity
50µl £180
100µl £234

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