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Anti-Myd88 (Phospho-Tyr257) Antibody

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Signalway Antibody
12764
Details
Description: Rabbit Polycolonal antibody to Myd88 (Phospho-Tyr257)
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polycolonal
Reactivity: Human, Mouse, Rat
UniProt: Q99836
Gene ID: 4615
Immunogen: A synthesized peptide derived from human Myd88 (Phospho-Tyr257)
Specificity: Myd88 (Phospho-Tyr257) Antibody detects endogenous levels of Myd88 only when phosphorylated at Tyr257
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Storage: Store at -20˚C

Target (Information from UniProt)
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Tissue Specificity: Ubiquitous.
Involvement in Disease: MYD88 deficiency: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.
Cellular Location: Cytoplasm.

Images
Western blot - Myd88 (Phospho-Tyr257) Antibody from Signalway Antibody (12764) - Antibody Supply Service
Western blot analysis Myd88 (Phospho-Tyr257) using nocodazole treated HeLa whole cell lysates

Product Code - 12764
Size Price Quantity
50µl £180
100µl £234

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