Anti-Growth Hormone AntibodyDatasheet
|Description:||Rat monoclonal (KT34) antibody to Growth hormone|
|Uniprot Protein Name:||Recommended name: Somatotropin Alternative name(s): Growth hormone|
|Uniprot Gene Name:||Name: GH1|
|Amino Acid Start:||1|
|Amino Acid End:||217|
Target (Information from UniProt)
|Function:||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|
|Involvement in Disease:||Growth hormone deficiency, isolated, 1A: An autosomal recessive, severe deficiency of growth hormone leading to dwarfism. Patients often develop antibodies to administered growth hormone.
Growth hormone deficiency, isolated, 1B: An autosomal recessive deficiency of growth hormone leading to short stature. Patients have low but detectable levels of growth hormone, significantly retarded bone age, and a positive response and immunologic tolerance to growth hormone therapy.
Kowarski syndrome: A syndrome clinically characterized by short stature associated with bioinactive growth hormone, normal or slightly increased growth hormone secretion, pathologically low insulin-like growth factor 1 levels, and normal catch-up growth on growth hormone replacement therapy.
Growth hormone deficiency, isolated, 2: An autosomal dominant deficiency of growth hormone leading to short stature. Clinical severity is variable. Patients have a positive response and immunologic tolerance to growth hormone therapy.
|Sequence Similarities:||Belongs to the somatotropin/prolactin family.|