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Anti-FPRL1 C-terminal Antibody

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Anogen
MO-P40006A
Overview
Name: Anti-FPRL1 C-terminal Antibody
Description: Mouse monoclonal antibody to FPRL1 C-terminal
Specificity: This monoclonal antibody reacts with the above mentioned peptide in ELISA and reacts with the 38KD FPRL1 on Western Blot.
Applications: ELISA, WB
Reactivity: Human
Cross Reactivity: Not identified
Immunogen: A short peptide corresponding to the C-terminal amino acid sequence (SASPPAETELQAM) on FPRL1 was conjugated with KLH for immunization.
Host: Mouse
Clonality: Monoclonal
Clone: C4F9
Isotype: IgG1
Formulation: Lyophilized from a solution in 0.01M PBS, pH 7.2

Target
Introduction: Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer’s disease.

Product Code - MO-P40006A
Size Price Quantity
100µg £297
500µg £448

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