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Anti-TNF-α Antibody

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Anogen
MO-C40003H
Overview
Name: Anti-TNF-α Antibody
Description: Mouse monoclonal antibody to human Tumor Necrosis Factor alpha (TNF-α)
Specificity: This antibody recognizes recombinant human TNF-α in ELISA and Western Blotting.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Purified recombinant human TNF-α
Host: Mouse
Clonality: Monoclonal
Clone: C4C7
Isotype: IgG1
Formulation: Lyophilized from a solution in 0.01M PBS, pH 7.0

Target
Introduction: Tumor Necrosis Factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine, mainly secreted by activated macrophages. TNF-α was named for its remarkable ability to cause hemorrhagic necrosis to tumors in mice. It is implicated with a variety of biological procedures including systemic inflammation, cell proliferation, apoptosis, lipid metabolism, and coagulation. The pleiotropic attribute of TNF-α regulation is associated with its ability to trigger multiple signalling pathways simultaneously. It is well documented that TNF-α functions through its receptors, TNFR1 (p55) and TNFR2 (p75). TNF-α not only contributes to the immune response to bacterial, fungal, viral and parasitic invasions, but also functions in tissue remodeling, autoimmune-diseases and the necrosis of specific tumors. TNF-α hyper-expression in response to some bacterial components such as LPS can cause life threatening septic shock. Recombinant TNF-α, in combination with chemotherapy, has been applied for treatment of soft sarcomas, melanomas and other irresectable tumors. Anti-TNF-α therapy has been used for treatment of rheumatoid arthritis.

Product Code - MO-C40003H
Size Price Quantity
100µg £267
500µg £388

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