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Anti-Factor B Antibody

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Absea Biotechnology
010110E04
Overview
Name: Anti-Factor B Antibody
Description: Mouse monoclonal (KT21) antibody to Factor B.
Applications: ELISA, sELISA 
Reactivity: Human
Immunogen: Purified Factor B from human blood.
Host: Mouse
Clonality: Monoclonal
Clone: KT21
Isotype: IgG2b
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target (Information from UniProt)
Function: Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Involvement in Disease: Hemolytic uremic syndrome atypical 4: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

Complement factor B deficiency: An immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
Sequence Similarities: Belongs to the peptidase S1 family.
Cellular Location: Secreted.
UniProt: P00751
Gene ID: 629
Synonyms: AHUS4 Antibody
B factor properdin Antibody
BF Antibody
BFD Antibody
C3 proaccelerator Antibody
C3 proactivator Antibody
C3/C5 convertase Antibody
CFAB Antibody
CFAB_HUMAN Antibody
CFB Antibody
Complement Factor B Antibody
Complement factor B Bb fragment Antibody
FB Antibody
FBI12 Antibody
GBG Antibody
Glycine rich beta glycoprotein Antibody
Glycine-rich beta glycoprotein Antibody
H2 Bf Antibody
H2BF Antibody
PBF2 Antibody
Properdin factor B Antibody

Images
Sandwich ELISA - Anti-Factor B Antibody from Absea Biotechnology (010110E04) - Antibody Supply Service
Sandwich ELISA usingKT21 coated plate and HRP conjugated KT24.

Product Code - 010110E04
Size Price Quantity
100µg £178
200µg £259
1mg £682

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