Anti-B2M Antibody (HRP)Datasheet
|Name:||Anti-B2M Antibody (HRP)|
|Description:||Mouse monoclonal (KT135) antibody to B2M (HRP).|
|Immunogen:||Purified native human B2M.|
|Purification:||IgG is purified through a Protein A column and labelled with horseradish peroxidase.|
|Concentration:||1 mg/ml in PBS containing 0.01% thimerosal as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
Target (Information from UniProt)
|Function:||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).|
|Involvement in Disease:||Immunodeficiency 43: A disorder characterized by marked reduction in serum concentrations of immunoglobulins and albumin, and hypoproteinemia due to hypercatabolism. Patients may suffer from recurrent respiratory tract infections and severe skin disease.
Amyloidosis 8: A form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
|Sequence Similarities:||Belongs to the beta-2-microglobulin family.|
|Post-Translational Modification:||Glycation of Ile-21 is observed in long-term hemodialysis patients.|
|Cellular Location:||Secreted. Cell surface.
Detected in serum and urine (PubMed:1336137, PubMed:7554280).
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Sandwich ELISA for purified B2M using KT134 coated plate and HRP conjugated KT135