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Anti-IgA Antibody

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Absea Biotechnology
Name: Anti-IgA Antibody
Description: Mouse monoclonal (KT40) antibody to IgA.
Applications: ELISA
Reactivity: Human
Immunogen: Recombinant human IgA2.
Host: Mouse
Clonality: Monoclonal
Clone: KT40
Isotype: IgG1
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target (Information from UniProt)
Function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Post-Translational Modification: 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
Cellular Location: Secreted. Cell membrane.
UniProt: P01876 / P01877
Synonyms: B lymphocyte-specific MB1 protein Antibody
B-cell antigen receptor complex-associated protein alpha chain Antibody
CD 79a Antibody
CD79a Antibody
CD79A antigen Antibody
CD79a antigen (immunoglobulin-associated alpha) Antibody
CD79a molecule, immunoglobulin-associated alpha Antibody
CD79A_HUMAN Antibody
Hepatocellular carcinoma-associated protein TB6 Antibody
Ig alpha Antibody
Ig alpha 1 chain C region Antibody
Ig alpha 2 chain C region Antibody
Ig-alpha Antibody
IGHA Antibody
IGHA1 Antibody
IGHA2 Antibody
IgM-alpha Antibody
Immunoglobulin heavy constant alpha 1 Antibody
Immunoglobulin heavy constant alpha 2 Antibody
Immunoglobulin heavy constant alpha 2 A2m marker Antibody
Immunoglobulin-associated alpha Antibody
Ly54 Antibody
MB-1 membrane glycoprotein Antibody
MB1 Antibody
Membrane-bound immunoglobulin-associated protein Antibody
PIgR Antibody
Poly-Ig receptor Antibody
polymeric immunoglobulin receptor Antibody
polymeric immunoglobulin receptor Secretory component Antibody
Surface IgM-associated protein Antibody

Cross-Reactivity Test - Anti-IgA Antibody from Absea Biotechnology (010106E09) - Antibody Supply Service
Cross-reactivity of KT40 to immunoglobulins with various isotypes.

Product Code - 010106E09
Size Price Quantity
200µg £259
1mg £682

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