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Anti-IgA Antibody

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Absea Biotechnology
010106E09
Details
Description: Mouse monoclonal (KT40) antibody to IgA
Category: Primary Antibodies
Applications: ELISA
Host: Mouse
Clonality: Monoclonal
Clone: KT40
Isotype: IgG1
Conjugate: Unconjugated
UniProt: P01876 / P01877
Antigen: IgA
Antigen Species: Human
Uniprot Protein Name: Ig alpha-1 chain C region Ig alpha-2 chain C region
Uniprot Gene Name: IGHA1, IGHA2
Sequence: Recombinant human IgA containing the constant regions of the heavy chain.

Target (Information from UniProt)
Function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
Post-Translational Modification: 3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
Cellular Location: Secreted. Cell membrane.

Product Code - 010106E09
Size Price Quantity
200µg £259
1mg £682

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