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Anti-CD63 Antibody

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Description: Mouse monoclonal (MEM-259) antibody to CD63
Category: Primary Antibodies
Applications: FC, IP, IHC-P, ICC
Host: Mouse
Clonality: Monoclonal
Clone: MEM-259
Isotype: IgG1
Reactivity: Human
Immunogen: HPB-ALL T cell line
Specificity: The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
Concentration: 1 mg/ml
Antigen: CD63
Introduction: CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.
Purity: > 95% (by SDS-PAGE)

Product Code - 11-343
Size Price Quantity
25µg £88
100µg £148

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