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Anti-SMC1A Antibody

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Absea Biotechnology
Name: Anti-SMC1A Antibody
Description: Rat monoclonal (KT73) antibody to SMC1A.
Applications: WB
Reactivity: Mouse
Immunogen: Recombinant mouse SMC1A (aa278 - aa513).
Amino Acid Start: 278
Amino Acid End: 513
Host: Rat
Clonality: Monoclonal
Clone: KT73
Isotype: IgM
Conjugate: Unconjugated
Product Form: Intact antibody in culture supernatant containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target (Information from UniProt)
Function: Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
Tissue Specificity: Ubiquitous (at protein level).
Sequence Similarities: Belongs to the SMC family. SMC1 subfamily.
Post-Translational Modification: Phosphorylated upon ionizing radiation or DNA methylation. Phosphorylation of Ser-957 and Ser-966 activates it and is required for S-phase checkpoint activation (By similarity).
Cellular Location: Nucleus. Chromosome. Chromosome > Centromere.

Associates with chromatin. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function (By similarity). Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
UniProt: Q9CU62
Gene ID: 24061
Synonyms: CDLS2 Antibody
Chromosome segregation protein SmcB Antibody
DKFZp686L19178 Antibody
DXhXs423e Antibody
DXS423E Antibody
KIAA0178 Antibody
MGC138332 Antibody
OTTHUMP00000061876 Antibody
RP6 29D12.1 Antibody
SB1.8 Antibody
Segregation of mitotic chromosomes 1 Antibody
Segregation of mitotic chromosomes like 1 Antibody
SMC 1 Antibody
SMC protein 1A Antibody
SMC protein 1B Antibody
SMC-1-alpha Antibody
SMC-1-beta Antibody
SMC-1A Antibody
SMC-1B Antibody
SMC1 Antibody
SMC1 (phospho S360) Antibody
SMC1 (phospho S957) Antibody
SMC1 (phospho S966) Antibody
SMC1 (structural maintenance of chromosomes 1 yeast) like 1 Antibody
SMC1 structural maintenance of chromosomes 1 like 1 Antibody
SMC1A (phospho S957) Antibody
SMC1alpha Antibody
SMC1alpha protein Antibody
SMC1A_HUMAN Antibody
SMC1B Antibody
SMC1BETA Antibody
SMC1beta protein Antibody
SMC1B_HUMAN Antibody
SMC1L1 Antibody
SMC1L2 Antibody
SMCB Antibody
Structural maintenance of chromosome 1 like 1 protein Antibody
Structural maintenance of chromosome 1 like 2 protein Antibody
Structural maintenance of chromosomes 1A Antibody
Structural maintenance of chromosomes 1B Antibody
Structural maintenance of chromosomes protein 1A Antibody
Structural maintenance of chromosomes protein 1B Antibody

Product Code - 160406E08S
Size Price Quantity
3ml £186
6ml £273
30ml £730

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